Effect of Metformin or Gliclazide on Lipid Peroxidation and Antioxidant Levels in Patients with Diabetes Mellitus
نویسندگان
چکیده
Aim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metformin.
منابع مشابه
Evaluation of the Salivary Total Antioxidant Capacity and Lipid Peroxidation Status in Type 2 Diabetes Mellitus Patients
Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial disorder with various disturbances in biochemical processes such as antioxidant status and lipid peroxidation. The aim of present study was evaluation of the oxidative stress markers in saliva of T2DM patients. Materials and Methods: In this study, 80 (40 T2DM and 40 control) individuals were assessed. The salivary total antioxidan...
متن کاملEvaluation of Lipid Peroxidation and Antioxidants Activity of Metformin in High Fructose Fed Diet Induced Type Ii Diabetic Rats
The purpose of this study was to investigate the possible antioxidant effect of metformin in high fructose fed diet-induced diabetic rats. The increased level of lipidperoxidation and altered levels of enzymatic and non enzymatic antioxidants were seen in high fructose fed consumed animals. The administration of metformin significantly normalized the altered levels of lipid peroxidation and ant...
متن کاملاثر درمان ترکیبی گلیکلازید و متفورمین در کنترل قند خون در بیماران دیابتی نوع 2
Background: Gliclazide is a second generation sulfonylurea which its efficacy and safety in the treatment of diabetes has been established. Diamicron MR (30 mg) is a new formulation of gliclazide with modified release which offer once daily dosage administration. This study was designed to assess the effect of combination therapy with diamicron and metformin in the treatment of type 2 diabetes....
متن کاملEnsete superbum ameliorates renal dysfunction in experimental diabetes mellitus
Objective(s):Hyperglycemia mediated oxidative stress plays a key role in the pathogenesis of diabetic complications like nephropathy. In the present study, we evaluated the effect of ethanolic extract of Ensete superbum seeds (ESSE) on renal dysfunction and oxidative stress in streptozotocin-induced diabetic rats. Materials and Methods:Glucose, HbA1c, total protein, albumin, renal function mar...
متن کاملComparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.
OBJECTIVE To compare the efficacy and tolerability of metformin, rosiglitazone and gliclazide MR as monotherapy and in combination in the treatment of type 2 diabetes. SUBJECTS AND METHODS 250 patients treated with oral antidiabetic agents for at least 24 weeks in monotherapy or in combination therapy were included in this retrospective study. RESULTS As monotherapy the reduction of fasting...
متن کامل